@article{22cc6699088f4c5f86d4b0f68bd83ae3,
title = "Cdk5 phosphorylation of ErbB4 is required for tangential migration of cortical interneurons",
abstract = "Interneuron dysfunction in humans is often associated with neurological and psychiatric disorders, such as epilepsy, schizophrenia, and autism. Some of these disorders are believed to emerge during brain formation, at the time of interneuron specification, migration, and synapse formation. Here, using a mouse model and a host of histological and molecular biological techniques, we report that the signaling molecule cyclin-dependent kinase 5 (Cdk5), and its activator p35, control the tangential migration of interneurons toward and within the cerebral cortex by modulating the critical neurodevelopmental signaling pathway, ErbB4/phosphatidylinositol 3-kinase, that has been repeatedly linked to schizophrenia. This finding identifies Cdk5 as a crucial signaling factor in cortical interneuron development in mammals.",
keywords = "cerebral cortex, interneurons, migration, mouse, phosphorylation",
author = "Sonja Raki{\'c} and Shigeaki Kanatani and David Hunt and Clare Faux and Anna Cariboni and Francesca Chiara and Shabana Khan and Olivia Wansbury and Beatrice Howard and Kazunori Nakajima and Margareta Nikoli{\'c} and Parnavelas, {John G.}",
note = "Funding Information: This work was supported by Wellcome Trust (grant numbers 074549 and 089775; J.G.P.), the Strategic Research Program for Brain Sciences (“Understanding of molecular and environmental bases for brain health”; K.N.), the Grant-in-Aid for Scientific Research of the Ministry of Education, Culture, Sports, Science, and Technology of Japan (K.N.) and grants from Breakthrough Breast Cancer (B.H.). Funding to pay the Open Access publication charges for this article was provided by the Wellcome Trust. Publisher Copyright: {\textcopyright} The Author 2013. Published by Oxford University Press.",
year = "2015",
month = apr,
day = "1",
doi = "10.1093/cercor/bht290",
language = "English",
volume = "25",
pages = "991--1003",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "4",
}