Characterisation of neural crest-derived stem cells in different tissues

研究成果: Chapter


A burst of recent findings has shown that neural crest-derived stem cells (NCSCs) reside in diverse mammalian tissues. In addition to tissues known to be derived from the neural crest, recent studies show that NCSCs exist in tissues that are not neural crest-derived, such as bone marrow. Although how NCSCs are defined has varied among reports to date, it is clear that NCSCs can self-renew and have the potential to differentiate into several different neural-crest lineages, including neurons, glial cells, myofibroblasts, melanocytes, adipocytes, chondrocytes, osteocytes, and connective tissues (Crane & Trainor, 2006; Delfino-Machin et al., 2007). NCSCs can express a wide range of characteristics, with their specific properties mainly depending on their tissue source and the animal’s ontogenic stage. The identification of NCSCs in this wide variety of tissues opens an entirely new approach for developing autologous cell replacement therapies for use in regenerative medicine.

ホスト出版物のタイトルNeural Crest Stem Cells
ホスト出版物のサブタイトルBreakthroughs and Applications
出版社World Scientific Publishing Co.
ISBN(印刷版)9814343803, 9789814343800
出版ステータスPublished - 2012 1月 1

ASJC Scopus subject areas

  • 生化学、遺伝学、分子生物学一般
  • 工学一般


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