Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA.

Yuki Haraguchi; Kanako Kuwasako; Yutaka Muto; Yoshitaka Bessho; Madoka Nishimoto; Shigeyuki Yokoyama; Akio Kanai; Gota Kawai; Taiichi Sakamoto

doi:10.1093/nass/nrp133

Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA.

Yuki Haraguchi
, Kanako Kuwasako
, Yutaka Muto
, Yoshitaka Bessho
, Madoka Nishimoto
, Shigeyuki Yokoyama
, Akio Kanai
, Gota Kawai
, Taiichi Sakamoto

研究成果: Article › 査読

1 被引用数 (Scopus)

抄録

SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.

本文言語	English
ページ（範囲）	265-266
ページ数	2
ジャーナル	Nucleic acids symposium series
号	53
DOI	https://doi.org/10.1093/nass/nrp133
出版ステータス	Published - 2009
外部発表	はい

ASJC Scopus subject areas

医学一般

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10.1093/nass/nrp133

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AU - Kuwasako, Kanako

AU - Muto, Yutaka

AU - Bessho, Yoshitaka

AU - Nishimoto, Madoka

AU - Yokoyama, Shigeyuki

AU - Kanai, Akio

AU - Kawai, Gota

AU - Sakamoto, Taiichi

PY - 2009

Y1 - 2009

N2 - SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.

AB - SELEX is a conventional method to obtain high affinity nucleic acids to target molecules. In this study, high affinity RNA molecules against SRP19 protein were selected by using a randomized library. The primary and predicted secondary structures of the aptamers are different from those of S-domain RNA which is the natural target of SRP19 protein. Comparison of structural features between S-domain RNA and aptamers might enhance our understanding on RNA-protein interaction.

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JO - Nucleic acids symposium series

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ER -

Characterization of RNA aptamers against SRP19 protein having sequences different from SRP RNA.

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