Chemoenzymatic synthesis of (2S,3S,4S)-form, the physiologically active stereoisomer of dehydroxymethylepoxyquinomicin (DHMEQ), a potent inhibitor on NF-κB

Keyphrases

• Potent Inhibitor 100%
• NF-B 100%
• Chemoenzymatic Synthesis 100%
• Dehydroxymethylepoxyquinomicin (DHMEQ) 100%
• Stereoisomers 100%
• Benzoquinone 25%
• Asymmetric Synthesis 25%
• Kinetic Resolution 25%
• Burkholderia Cepacia Lipase 25%
• Tert-butyl Hydroperoxide (t-BHP) 25%
• Enantiomerically Pure 25%
• Chemoenzymatic Approach 25%
• Asymmetric Epoxidation 25%
• Enzyme-catalyzed 25%
• Catalytic Kinetics 25%
• Lipase-catalyzed Hydrolysis 25%

Biochemistry, Genetics and Molecular Biology

• Stereoisomerism 100%
• Enzyme 50%
• Precursor 50%
• Enzymatic Hydrolysis 50%
• Triacylglycerol Lipase 50%
• Pancreatic Lipase 50%
• Epoxidation 50%
• Enantiomer 50%
• Asymmetric Synthesis 50%
• Burkholderia cepacia 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Dehydroxymethylepoxyquinomicin 100%
• Pancreatic Lipase 25%
• Enzymes 25%
• 1,4 Benzoquinone 25%
• Tert Butyl Hydroperoxide 25%
• Burkholderia cepacia 25%