Chromatography-free synthesis of Corey's intermediate for Tamiflu

Makoto Furutachi; Naoya Kumagai; Takumi Watanabe; Masakatsu Shibasaki

doi:10.1016/j.tet.2014.09.081

Chromatography-free synthesis of Corey's intermediate for Tamiflu

Makoto Furutachi
, Naoya Kumagai
, Takumi Watanabe
, Masakatsu Shibasaki

研究成果: Article › 査読

4 被引用数 (Scopus)

抄録

Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.

本文言語	English
ページ（範囲）	9113-9117
ページ数	5
ジャーナル	Tetrahedron
巻	70
号	47
DOI	https://doi.org/10.1016/j.tet.2014.09.081
出版ステータス	Published - 2014 11月 25
外部発表	はい

ASJC Scopus subject areas

生化学
創薬
有機化学

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10.1016/j.tet.2014.09.081

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引用スタイル

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abstract = "Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.",

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AU - Furutachi, Makoto

AU - Kumagai, Naoya

AU - Watanabe, Takumi

AU - Shibasaki, Masakatsu

PY - 2014/11/25

Y1 - 2014/11/25

N2 - Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.

AB - Column chromatography-free stereoselective synthesis of Corey's intermediate for Tamiflu (oseltamivir phosphate) was achieved, starting from l-glutamic acid γ-ethyl ester. The reagents and solvents used in the reaction scheme are industrially tractable, rendering the synthesis a potential starting point for process research.

KW - Chromatography-free synthesis

KW - Corey's intermediate

KW - Stereoselective synthesis

KW - Tamiflu

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Chromatography-free synthesis of Corey's intermediate for Tamiflu

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