Chronic Spinal Cord Injury Regeneration with Combined Therapy Comprising Neural Stem/Progenitor Cell Transplantation, Rehabilitation, and Semaphorin 3A Inhibitor

Takashi Yoshida, Syoichi Tashiro, Narihito Nagoshi, Munehisa Shinozaki, Takahiro Shibata, Mitsuhiro Inoue, Shoji Ogawa, Shinsuke Shibata, Tetsuya Tsuji, Hideyuki Okano, Masaya Nakamura

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Spinal cord injury (SCI) often results in various long-term sequelae, and chronically injured spinal cords exhibit a refractory feature, showing a limited response to cell transplantation therapies. To our knowl-edge, no preclinical studies have reported a treatment approach with results surpassing those of treatment comprising rehabilitation alone. In this study of rats with SCI, we propose a novel combined therapy involving a semaphorin 3A inhibitor (Sema3Ai), which enhances axonal regeneration, as the third treatment element in combination with neural stem/progenitor cell transplantation and rehabili-tation. This comprehensive therapeutic strategy achieved significant improvements in host-derived neuronal and oligodendrocyte differentiation at the SCI epicenter and promoted axonal regeneration even in the chronically injured spinal cord. The elongated axons established functional electrical con-nections, contributing to significant enhancements in locomotor mobility when compared with animals treated with transplantation and rehabilitation. As a result, our combined transplantation, Sema3Ai, and rehabilitation treatment have the potential to serve as a critical step forward for chronic SCI patients, improving their ability to regain motor function.

本文言語English
論文番号ENEURO.0378-23.2024
ジャーナルeNeuro
11
2
DOI
出版ステータスPublished - 2024

ASJC Scopus subject areas

  • 神経科学一般

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