Clinical presentation and diagnosis of toxoplasmic encephalitis in Japan

Naoya Sakamoto, Takuya Maeda, Kei Mikita, Yasuyuki Kato, Naoki Yanagisawa, Akihiko Suganuma, Akifumi Imamura, Fukumi Nakamura-Uchiyama, Yasushi Miyahira, Akihiko Kawana, Kenji Ohnishi, Atsushi Ajisawa

研究成果: Article査読

8 被引用数 (Scopus)


Distinguishing life-threatening toxoplasmic encephalitis (TE) from brain lymphoma in patients with acquired immunodeficiency syndrome (AIDS) may be difficult. Empiric anti-toxoplasmosis treatment is often initiated because of the reluctance in performing brain biopsies, which may delay the diagnosis and treatment of brain lymphoma in Japan. In this study, we retrospectively examined the clinical characteristics of 13 AIDS patients with TE in Japan, including magnetic resonance imaging and thallium 201 (201TI) single photon emission computed tomography (SPECT) findings, cerebral spinal fluid analysis, serology, and polymerase chain reaction (PCR) results. All patients improved on anti-toxoplasmosis treatment. Of the 11 patients who underwent serological testing, 6 (55%) had a positive serological result. Of the 7 patients who underwent PCR testing, 3 (42.9%) had a positive PCR result. Nine of 11 patients with TE (81.8%) had multiple lesions. Analysis of the sites of TE lesions did not reveal a difference in site predilection between TE and brain lymphoma. Uptake was negative in all 9 patients who underwent 201Tl SPECT. The study findings suggest that toxoplasma serostatus and PCR may be used to discriminate TE from brain lymphoma. No focal accumulation of 201TI is strongly suggestive of TE in patients with AIDS in Japan.

ジャーナルParasitology International
出版ステータスPublished - 2014 10月

ASJC Scopus subject areas

  • 寄生虫科
  • 感染症


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