Coculture of a Pathogenic Actinomycete and Animal Cells to Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect

Yasumasa Hara; Midori A. Arai; Kazufumi Toume; Hyuma Masu; Tomoyuki Sato; Katsuko Komatsu; Takashi Yaguchi; Masami Ishibashi

doi:10.1021/acs.orglett.8b02522

Coculture of a Pathogenic Actinomycete and Animal Cells to Produce Nocarjamide, a Cyclic Nonapeptide with Wnt Signal-Activating Effect

Yasumasa Hara
, Midori A. Arai
, Kazufumi Toume
, Hyuma Masu
, Tomoyuki Sato
, Katsuko Komatsu
, Takashi Yaguchi
, Masami Ishibashi

研究成果: Article › 査読

22 被引用数 (Scopus)

抄録

A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct and emulate the initial infection state, and a new cyclic nonapeptide, named nocarjamide (1), was obtained by coculture of Nocardia tenerifensis IFM 10554^T and the mouse macrophage-like cell line J774.1 in a modified Czapek-Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects.

本文言語	English
ページ（範囲）	5831-5834
ページ数	4
ジャーナル	Organic Letters
巻	20
号	18
DOI	https://doi.org/10.1021/acs.orglett.8b02522
出版ステータス	Published - 2018 9月 21
外部発表	はい

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

文献へのアクセス

10.1021/acs.orglett.8b02522

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引用スタイル

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abstract = "A coculture method with a pathogenic actinomycete of the genus Nocardia and an animal cell line was designed to reconstruct and emulate the initial infection state, and a new cyclic nonapeptide, named nocarjamide (1), was obtained by coculture of Nocardia tenerifensis IFM 10554T and the mouse macrophage-like cell line J774.1 in a modified Czapek-Dox medium. Nocarjamide (1) exhibited Wnt signal-activating effects.",

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AU - Hara, Yasumasa

AU - Arai, Midori A.

AU - Toume, Kazufumi

AU - Masu, Hyuma

AU - Sato, Tomoyuki

AU - Komatsu, Katsuko

AU - Yaguchi, Takashi

AU - Ishibashi, Masami

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