Collagen Hollow Microbeads for Engineered Hollow Organ Model in Vitro

Satona Abeta, Akari Masuda, Aiki Hioki, Kayoko Shoji, Hiroaki Onoe

研究成果: Conference contribution

抄録

We propose an in vitro model to mimic the hollow structure of biological tissues (e.g. heart or stomach) using hollow core-shell collagen microgel beads. By using collagen hydrogel as the shell of the microbeads, cells encapsulated inside of the collagen shell can proliferate and form a tissue structure with a hollow center. In this paper, as a first step toward engineered hollow structure tissue formation, we report a fabrication method for core-shell (hollow) alginate microgel beads by a simple droplet-dipping method using a two-layer coaxial nozzle device. To apply collagen hydrogel to this droplet-dipping method, we applied alginate cross-linking network as a template for creating collagen microgel beads and dissolved the alginate network after the collagen hydrogel was stabilized. By combining these techniques, we believe that hollow collagen microgel beads encapsulating cells can easily and massively be produced for reconstructing in vitro hollow organ models.

本文言語English
ホスト出版物のタイトルIEEE 37th International Conference on Micro Electro Mechanical Systems, MEMS 2024
出版社Institute of Electrical and Electronics Engineers Inc.
ページ477-480
ページ数4
ISBN(電子版)9798350357929
DOI
出版ステータスPublished - 2024
イベント37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024 - Austin, United States
継続期間: 2024 1月 212024 1月 25

出版物シリーズ

名前Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
ISSN(印刷版)1084-6999

Conference

Conference37th IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2024
国/地域United States
CityAustin
Period24/1/2124/1/25

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 凝縮系物理学
  • 機械工学
  • 電子工学および電気工学

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