TY - GEN
T1 - Comparative study on bioresorbability of chelate-setting cements with various calcium-phosphate phase using rabbit model
AU - Konishi, Toshiisa
AU - Takahashi, Shuhei
AU - Mizumoto, Minori
AU - Honda, Michiyo
AU - Kida, Koki
AU - Horiguchi, Yukiko
AU - Oribe, Kazuya
AU - Ishii, Ken
AU - Morisue, Hikaru
AU - Toyama, Yoshiaki
AU - Matsumoto, Morio
AU - Aizawa, Mamoru
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - We have developed novel calcium-phosphate cements (CPCs) based on the chelate-setting mechanism of inositol phosphate (IP6) using hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP) and α-TCP as starting materials. These cements (IP6-HAp, IP6-β-TCP and IP6-α-TCP cements) have different bioresorbability due to the chemical composition of starting materials. In the present study, biocompatibility and bioresorbability of the above three cements and commercially available cement (BiopexR-R) was histologically evaluated in vivo using rabbit model for 4, 8, and 24 weeks, in addition to their dissolution in vitro. The dissolution of these cements increased in the order of IP6-HAp, IP6-β-TCP and IP6-α-TCP cements. The newly-formed bones were directly in contact with both the IP6-HAp and BiopexR-R cement specimens. As for the IP6-β-TCP and IP6-α-TCP cements, newly-formed bones were formed time-dependently slightly apart from the cement specimens. Resorption rate for BiopexR-R, IP6-HAp, IP6-β-TCP, and IP6-α-TCP cements after 24 weeks implantation were of 7.2, 5.0, 13.7, and 16.2%, respectively, compared to original cements. The present chelate-setting cements with different bioresorbability are promising candidates for application as the novel CPCs.
AB - We have developed novel calcium-phosphate cements (CPCs) based on the chelate-setting mechanism of inositol phosphate (IP6) using hydroxyapatite (HAp), β-tricalcium phosphate (β-TCP) and α-TCP as starting materials. These cements (IP6-HAp, IP6-β-TCP and IP6-α-TCP cements) have different bioresorbability due to the chemical composition of starting materials. In the present study, biocompatibility and bioresorbability of the above three cements and commercially available cement (BiopexR-R) was histologically evaluated in vivo using rabbit model for 4, 8, and 24 weeks, in addition to their dissolution in vitro. The dissolution of these cements increased in the order of IP6-HAp, IP6-β-TCP and IP6-α-TCP cements. The newly-formed bones were directly in contact with both the IP6-HAp and BiopexR-R cement specimens. As for the IP6-β-TCP and IP6-α-TCP cements, newly-formed bones were formed time-dependently slightly apart from the cement specimens. Resorption rate for BiopexR-R, IP6-HAp, IP6-β-TCP, and IP6-α-TCP cements after 24 weeks implantation were of 7.2, 5.0, 13.7, and 16.2%, respectively, compared to original cements. The present chelate-setting cements with different bioresorbability are promising candidates for application as the novel CPCs.
KW - Biocompatibility
KW - Bioresorbability
KW - Bone graft
KW - Calcium-phosphate cement
KW - Inositol hexaphosphate
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=84871342975&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84871342975&partnerID=8YFLogxK
U2 - 10.4028/www.scientific.net/KEM.529-530.167
DO - 10.4028/www.scientific.net/KEM.529-530.167
M3 - Conference contribution
AN - SCOPUS:84871342975
SN - 9783037855171
T3 - Key Engineering Materials
SP - 167
EP - 172
BT - Bioceramics 24
PB - Trans Tech Publications Ltd
T2 - 24th Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2012
Y2 - 21 October 2012 through 24 October 2012
ER -