Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans

Hitoshi Sawa, Hiroko Kouike, Hideyuki Okano

研究成果: Article査読

80 被引用数 (Scopus)

抄録

Asymmetric cell division is a fundamental process that produces cellular diversity during development. We have identified two mutants in C. elegans (psa-1 and psa-4) in which the asymmetry of T cell division is disrupted. psa-1 and psa-4 encode homologs of yeast SW13 and SW12/SNF2, respectively, which are components of the SWI/SNF complex. We show by RNA interference assay that homologs of other components of SWI/SNF are also involved in T cell division. psa-1 and psa-4 are likely to be required in the T cell during mitosis to cause asymmetric cell division. Because the SWI/SNF complex is required for asymmetric division in S. cerevisiae, these results demonstrate that at least some aspects of the mechanism of asymmetric cell division are conserved between yeast and a multicellular organism.

本文言語English
ページ(範囲)617-624
ページ数8
ジャーナルMolecular Cell
6
3
DOI
出版ステータスPublished - 2000
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞生物学

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