Concurrent de novo Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review

Rie Sakata, Po Sung Chu, Miho Kawaida, Katsura Emoto, Masatoshi Sakurai, Risa Nishida, Keisuke Asakura, Rei Morikawa, Nobuhito Taniki, Keisuke Kataoka, Takanori Kanai, Nobuhiro Nakamoto

研究成果: Article査読

抄録

The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is induced after thymectomy remains to be elucidated. We herein present the case of a 50-year-old lady with concurrent de novo type 1 autoimmune hepatitis (AIH) and pure red cell aplasia (PRCA), 1 month after undergoing a successful total thymectomy for combined squamous cell carcinoma and thymoma (Masaoka stage II). Corticosteroids yielded short-term effects for both AIH and PRCA. Literature on thymoma-associated AIH, an extremely rare immune-related comorbidity, was also reviewed.

本文言語English
ページ(範囲)243-249
ページ数7
ジャーナルInternal Medicine
62
2
DOI
出版ステータスPublished - 2023

ASJC Scopus subject areas

  • 内科学

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