Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance

Tomohiro Minakawa; Kazufumi Toume; Firoj Ahmed; Samir Kumar Sadhu; Takashi Ohtsuki; Midori A. Arai; Masami Ishibashi

doi:10.1248/cpb.58.1549

Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance

Tomohiro Minakawa
, Kazufumi Toume
, Firoj Ahmed
, Samir Kumar Sadhu
, Takashi Ohtsuki
, Midori A. Arai
, Masami Ishibashi

研究成果: Article › 査読

10 被引用数 (Scopus)

抄録

In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

本文言語	English
ページ（範囲）	1549-1551
ページ数	3
ジャーナル	Chemical and Pharmaceutical Bulletin
巻	58
号	11
DOI	https://doi.org/10.1248/cpb.58.1549
出版ステータス	Published - 2010 11月
外部発表	はい

ASJC Scopus subject areas

化学一般
創薬

文献へのアクセス

10.1248/cpb.58.1549

他のファイルとリンク

フィンガープリント

「Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{53c73b572d744e31a415d18d1fbf8922,

title = "Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance",

abstract = "In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.",

keywords = "Flavanone, Pongamia pinnata, Screening",

author = "Tomohiro Minakawa and Kazufumi Toume and Firoj Ahmed and Sadhu, \{Samir Kumar\} and Takashi Ohtsuki and Arai, \{Midori A.\} and Masami Ishibashi",

year = "2010",

month = nov,

doi = "10.1248/cpb.58.1549",

language = "English",

volume = "58",

pages = "1549--1551",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "11",

}

TY - JOUR

T1 - Constituents of Pongamia pinnata isolated in a screening for activity to overcome tumor necrosis factor-related apoptosis-inducing ligand-resistance

AU - Minakawa, Tomohiro

AU - Toume, Kazufumi

AU - Ahmed, Firoj

AU - Sadhu, Samir Kumar

AU - Ohtsuki, Takashi

AU - Arai, Midori A.

AU - Ishibashi, Masami

PY - 2010/11

Y1 - 2010/11

N2 - In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

AB - In a search for natural products with activity to overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance, we performed the bioassay-guided fractionation of a semi mangrove, Pongamia pinnata, collected from Bangladesh, and isolated a new compound, (2S)-(2″,3″:7,8)- furanoflavanone (1), along with six known flavonoids (2-7). Two of the compounds significantly overcame TRAIL-resistance in human gastric adenocarcinoma (AGS) cell lines.

KW - Flavanone

KW - Pongamia pinnata

KW - Screening

UR - https://www.scopus.com/pages/publications/78049476977

UR - https://www.scopus.com/pages/publications/78049476977#tab=citedBy

U2 - 10.1248/cpb.58.1549

DO - 10.1248/cpb.58.1549

M3 - Article

C2 - 21048354

AN - SCOPUS:78049476977

SN - 0009-2363

VL - 58

SP - 1549

EP - 1551

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 11

ER -