Construction of epidithiodioxopiperazines by directed oxidation of hydroxyproline-derived dioxopiperazines

Larry E. Overman; Takaaki Sato

doi:10.1021/ol702518t

Construction of epidithiodioxopiperazines by directed oxidation of hydroxyproline-derived dioxopiperazines

Larry E. Overman
, Takaaki Sato

研究成果: Article › 査読

52 被引用数 (Scopus)

抄録

(Chemical Equation Presented) Functionalization of the angular methine carbon of hydroxyproline-derived dioxopiperazines by a radical-promoted C-H bond oxidation, which is directed by a proximal (bromomethyl)silyl group, is described. This regioselective oxidation is the key step in a new synthesis of epidithiodioxopiperazines.

本文言語	English
ページ（範囲）	5267-5270
ページ数	4
ジャーナル	Organic Letters
巻	9
号	25
DOI	https://doi.org/10.1021/ol702518t
出版ステータス	Published - 2007 12月 6
外部発表	はい

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol702518t

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abstract = "(Chemical Equation Presented) Functionalization of the angular methine carbon of hydroxyproline-derived dioxopiperazines by a radical-promoted C-H bond oxidation, which is directed by a proximal (bromomethyl)silyl group, is described. This regioselective oxidation is the key step in a new synthesis of epidithiodioxopiperazines.",

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N2 - (Chemical Equation Presented) Functionalization of the angular methine carbon of hydroxyproline-derived dioxopiperazines by a radical-promoted C-H bond oxidation, which is directed by a proximal (bromomethyl)silyl group, is described. This regioselective oxidation is the key step in a new synthesis of epidithiodioxopiperazines.

AB - (Chemical Equation Presented) Functionalization of the angular methine carbon of hydroxyproline-derived dioxopiperazines by a radical-promoted C-H bond oxidation, which is directed by a proximal (bromomethyl)silyl group, is described. This regioselective oxidation is the key step in a new synthesis of epidithiodioxopiperazines.

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Construction of epidithiodioxopiperazines by directed oxidation of hydroxyproline-derived dioxopiperazines

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