Measuring oxygen pressure within an artery is essential for providing information on blood perfusion. Optic-sensor is particularly well suited for oxygen pressure measurement because electrolytic or magnetic changes of the environment do not affect the measurement. We developed a fiber optical sensor based on phosphorescence quenching method. The probe, Pd-meso-tetra(4-carboxyphenyl)porphyrin, was immobilized to the silicone resin membrane, which has high oxygen permeability, and attached to the tip of POF (outer diameter: 500μm). The light source used for exciting the probe was a Nd:YAG-SH pulse laser (532nm) and the phosphorescent emission was detected by a photomultiplier tube. The signal was fitted to a single exponential decay curve to acquire the time constant (life time), thereafter the oxygen pressure was calculated from Stern-Volmer relationship. Effectiveness of the sensor was obtained to measure the dissolved oxygen with high precision (correlation coefficient 0.999) and high response time (about 7sec). In this study, measurement of oxygen pressure was also made in femoral artery of rat by using the developed sensor and it indicated that it was very useful to measure arterial oxygen pressure continuously.
|ジャーナル||Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings|
|出版ステータス||Published - 2002|
|イベント||Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States|
継続期間: 2002 10月 23 → 2002 10月 26
ASJC Scopus subject areas
- コンピュータ ビジョンおよびパターン認識