Control of telomerase function on SPR sensor using polymer particles

Ryuji Hara; Kazunobu Toshima; Haruma Kawaguchi

Control of telomerase function on SPR sensor using polymer particles

Ryuji Hara, Kazunobu Toshima, Haruma Kawaguchi

応用化学科

研究成果: Paper › 査読

抄録

The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.

本文言語	English
ページ数	1
出版ステータス	Published - 2006 10月 19
イベント	55th SPSJ Annual Meeting - Nagoya, Japan 継続期間: 2006 5月 24 → 2006 5月 26

Other

Other	55th SPSJ Annual Meeting
国/地域	Japan
City	Nagoya
Period	06/5/24 → 06/5/26

ASJC Scopus subject areas

工学（全般）

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引用スタイル

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title = "Control of telomerase function on SPR sensor using polymer particles",

abstract = "The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.",

keywords = "Ethidium bromide, Polymer particle, SPR (surface plasmon resonance), Telomerase inhibitor, Telomere",

author = "Ryuji Hara and Kazunobu Toshima and Haruma Kawaguchi",

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T1 - Control of telomerase function on SPR sensor using polymer particles

AU - Hara, Ryuji

AU - Toshima, Kazunobu

AU - Kawaguchi, Haruma

PY - 2006/10/19

Y1 - 2006/10/19

N2 - The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.

AB - The interaction of G-quadruplex (G4) DNA with telomerase inhibitors was investigated using SPR sensor. SPR signal was enhanced with polymer particle on which inhibitor was immobilized. The relation among molecular structure of inhibitors, inhibition activity and the effect of polymer particles was discussed. And we also evaluated stabilization ability of G4 by SPR signal of annealing between G4 and telomerase RNA (tR). The results suggested polymer particle led to SPR signal enhancement of interaction between G4 and telomerase inhibitors and the property of inhibitors immobilized on particle was unchanged.

KW - Ethidium bromide

KW - Polymer particle

KW - SPR (surface plasmon resonance)

KW - Telomerase inhibitor

KW - Telomere

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M3 - Paper

AN - SCOPUS:33749851842

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Control of telomerase function on SPR sensor using polymer particles

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