Controlled dissolution of phenytoin by hybridizing with silica nanoparticles

H. Goto, T. Isobe, M. Senna

研究成果: Article査読

7 被引用数 (Scopus)


A sparingly soluble model drug, phenytoin (5,5-diphenyl-hydantoin, denoted as PT), was incorporated during or after hydrolysis and polycondensation of tetra orthoethyl silicate (TEOS) to obtain silica-drug hybrids. We also compare the hybrids obtained by sol-gel process with those obtained by simple adsorption on nonporous silica particles. The initial rate of dissolution in water increases by a factor of 40 with respect to the intact PT by aging silica before drug addition. The IR results show that vC=O in the position 2 of PT and vN-H shift toward the higher wavenumber, showing that intermolecular hydrogen bonds between C=O and N-H are loosened or broken to form new hydrogen bonds between C=O in PT and Si-OH in silica. The dissolution rate of PT is determined by the degree of the breakage of hydrogen bonds between PT molecules and the intensity of the interaction between silica and PT.

ジャーナルJournal of Nanoparticle Research
出版ステータスPublished - 1999

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 化学一般
  • 原子分子物理学および光学
  • モデリングとシミュレーション
  • 材料科学一般
  • 凝縮系物理学


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