@article{03c0f7f7efab40299b9f3987d5b6ab2d,
title = "Convenient synthesis of spiroindole derivatives via palladium-catalyzed cyclization of propargyl chlorides",
abstract = "Abstract Herein, we report the palladium-catalyzed cyclization reactions of indoles bearing a propargyl chloride side chain at their 3-position. In the presence of an external nucleophile, such as a sulfonamide or malonate, indoles bearing a propargyl group at their 3-position gave fused tetracyclic spiroindolines preferentially. However, in the absence of an external nucleophile, the same substrates afforded spiroindoles. Our attempts to develop a catalytic asymmetric spirocyclization onto a propargylpalladium species are also presented in this paper.",
keywords = "Cascade cyclization, Catalytic asymmetric reaction, Palladium, Spiroindole",
author = "Akira Iwata and Shinsuke Inuki and Shinya Oishi and Nobutaka Fujii and Hiroaki Ohno",
note = "Funding Information: This work was supported by a Grant-in-Aid for the Encouragement of Young Scientists (A) from JSPS, Japan; Platform for Drug Design, Discovery, and Development from MEXT, Japan; research Grants from Takeda Science Foundation . A.I. and S.I. are grateful for Research Fellowships from the Japan Society for the Promotion of Science (JSPS) for Young Scientists. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",
year = "2015",
month = aug,
day = "7",
doi = "10.1016/j.tet.2015.05.006",
language = "English",
volume = "71",
pages = "6580--6585",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "37",
}