Corneal epithelium following penetrating keratoplasty

K. Tsubota, Y. Mashima, H. Murata, M. Yamada, N. Sato

研究成果: Article査読

22 被引用数 (Scopus)


Aims - This study was designed to observe any changes to the corneal epithelium after penetrating keratoplasty. Methods - The corneal epithelia of 26 patients were observed by specular microscopy 1 week, 1 month, 3 months, and 6 months following penetrating keratoplasty. Results - After re-epithelialisation was confirmed by biomicroscopy 1 week after surgery, specular microscopy revealed many abnormal cells, including spindle shaped cells, nucleated cells, large cells, as well as irregular cell configurations. Although these abnormal findings tended to decrease with time, they were still present in some cases as much as 6 months postoperatively. Computerised morphometric analysis yielded mean cell areas of 1121 (SD 168) (μm2, 1139 (675) μm2, 1712 (496) μm2, and 1400 (377) μm2 at 1 week, 1 month, 3 months, and 6 months respectively, all significantly greater than that of age matched controls (710 (151) μm2). The shape factor decreased with time, but was still greater than the control level at 6 months. Conclusion - This study demonstrates that epithelial abnormalities persist longer than expected after penetrating keratoplasty, and that these subtle changes can be detected by specular microscopic observation, potentially allowing for modification and enhancement of the wound healing process.

ジャーナルBritish Journal of Ophthalmology
出版ステータスPublished - 1995

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学


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