抄録
Rabbit antisera have been made to the C-terminal octapeptide of bovine MIP26K (residues 256-263) and to an octapeptide near the C-terminus (residues 252-259). Use of these antisera in Western blot analysis of membrane from young vs old human lenses, and from cortex vs nucleus of old human lenses, suggest age-related covalent changes in the C-terminus of MIP26K. These age-related changes in anti-256-263 and anti-252-259 sera can be mimicked by treatment of lens membrane with carboxypeptidase Y, suggesting the loss of 1-8 amino acid residues from the C-terminus of the 26,000 dalton form of MIP26K during aging of the normal human lens.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 443-446 |
| ページ数 | 4 |
| ジャーナル | Investigative Ophthalmology and Visual Science |
| 巻 | 27 |
| 号 | 3 |
| 出版ステータス | Published - 1986 1月 1 |
ASJC Scopus subject areas
- 眼科学
- 感覚系
- 細胞および分子神経科学