Creation of pure nanodrugs and their anticancer properties

Hitoshi Kasai; Tatsuya Murakami; Yoshikazu Ikuta; Yoshitaka Koseki; Koichi Baba; Hidetoshi Oikawa; Hachiro Nakanishi; Masahiro Okada; Mitsuru Shoji; Minoru Ueda; Hiroshi Imahori; Mitsuru Hashida

doi:10.1002/anie.201204596

Creation of pure nanodrugs and their anticancer properties

Hitoshi Kasai, Tatsuya Murakami, Yoshikazu Ikuta, Yoshitaka Koseki, Koichi Baba, Hidetoshi Oikawa, Hachiro Nakanishi, Masahiro Okada, Mitsuru Shoji, Minoru Ueda, Hiroshi Imahori, Mitsuru Hashida

薬科学科

研究成果: Article › 査読

128 被引用数 (Scopus)

抄録

A method for preparing nanoparticles of a water-insoluble drug that are suitable for administration to the human body has been established. A reprecipitation method was used to fabricate 50 nm nanoparticles of dimerized SN-38, an anticancer camptothecin derivative, that form stable aqueous dispersions and can penetrate into cancer cells to inhibit cell proliferation more potently than irinotecan.

本文言語	English
ページ（範囲）	10315-10318
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	51
号	41
DOI	https://doi.org/10.1002/anie.201204596
出版ステータス	Published - 2012 10月 8

ASJC Scopus subject areas

触媒
化学 (全般)

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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AU - Kasai, Hitoshi

AU - Murakami, Tatsuya

AU - Ikuta, Yoshikazu

AU - Koseki, Yoshitaka

AU - Baba, Koichi

AU - Oikawa, Hidetoshi

AU - Nakanishi, Hachiro

AU - Okada, Masahiro

AU - Shoji, Mitsuru

AU - Ueda, Minoru

AU - Imahori, Hiroshi

AU - Hashida, Mitsuru

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KW - drug delivery

KW - drug design

KW - nanoparticles

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Creation of pure nanodrugs and their anticancer properties

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ASJC Scopus subject areas

UN SDG

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