Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells

Takeshi Shimaoka, Ken Ichiro Seino, Noriaki Kume, Manabu Minami, Chiyoko Nishime, Makoto Suematsu, Toru Kita, Masaru Taniguchi, Kouji Matsushima, Shin Yonehara

研究成果: Article査読

49 被引用数 (Scopus)


The transmembrane chemokine CXCL 16 (CXCL16), which is the same molecule as the scavenger receptor that binds phosphatidylserine and oxidized lipoprotein (SR-PSOX), has been shown to mediate chemotaxis and adhesion of CXC chemokine receptor 6-expressing cells such as NKT and activated Th1 cells. We generated SR-PSOX/CXCL16-deficient mice and examined the role of this chemokine in vivo. The mutant mice showed a reduced number of liver NKT cells, and decreased production of IFN-γ and IL-4 by administration of α- galactosylceramide (αGalCer). Of note, the αGalCer-induced production of IFN-γ was more severely impaired than the production of IL-4 in SR-PSOX-deficient mice. In this context, SR-PSOX-deficient mice showed impaired sensitivity to αGalCer-induced anti-tumor effect mediated by IFN-γ from NKT cells. NKT cells from wild-type mice showed impaired production of IFN-γ, but not IL-4, after their culture with αGalCer and APCs from mutant mice. Moreover, Propionibacterium acnes-induced in vivo Th1 responses were severely impaired in SR-PSOX-deficient as well as NKT KO mice. Taken together, SR-PSOX/CXCL16 plays an important role in not only the production of IFN-γ by NKT cells, but also promotion of Th1-inclined immune responses mediated by NKT cells.

ジャーナルJournal of Immunology
出版ステータスPublished - 2007 12月 15

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学


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