TY - JOUR
T1 - Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury
T2 - a review
AU - Tashiro, Syoichi
AU - Tsuji, Osahiko
AU - Shinozaki, Munehisa
AU - Shibata, Takahiro
AU - Yoshida, Takashi
AU - Tomioka, Yohei
AU - Unai, Kei
AU - Kondo, Takahiro
AU - Itakura, Go
AU - Kobayashi, Yoshiomi
AU - Yasuda, Akimasa
AU - Nori, Satoshi
AU - Fujiyoshi, Kanehiro
AU - Nagoshi, Narihito
AU - Kawakami, Michiyuki
AU - Uemura, Osamu
AU - Yamada, Shin
AU - Tsuji, Tetsuya
AU - Okano, Hideyuki
AU - Nakamura, Masaya
N1 - Funding Information:
This work was supported by The General Insurance Association of Japan, a general research fund for the department of rehabilitation medicine in Kyorin university school of medicine, and by funding from the Japan Agency for Medical Research and Development (AMED) (Grant Number JP20bm0204001, JP19bm0204001, and JP18bk0104017 to H.O. and M.N.).
Funding Information:
M.N. declared a consultancy role with K‐Pharma Inc. and research funding from RMic and Hisamitsu. H.O. declared a leadership position at Keio University School of Medicine and is a compensated scientific consultant for San Bio Co. Ltd. and K Pharma Inc. The remaining authors declare no competing interests.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Stem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic effects, feasibility, non-invasiveness, and diverse and systemic properties. In this review article, we summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of SCI. Although conventional rehabilitative methods have commonly been implemented alone, especially in studies of acute-to-subacute SCI, the combinatorial effects of intensive and advanced methods, including various neurorehabilitative approaches, have also been reported. Separating the concept of combined rehabilitation from regenerative rehabilitation, we suggest that the main roles of regenerative rehabilitation can be categorized as conditioning/reconditioning, functional training, and physical exercise, all of which are indispensable for enhancing functional recovery achieved using stem cell therapies.
AB - Stem cell-based regenerative therapy has opened an avenue for functional recovery of patients with spinal cord injury (SCI). Regenerative rehabilitation is attracting wide attention owing to its synergistic effects, feasibility, non-invasiveness, and diverse and systemic properties. In this review article, we summarize the features of rehabilitation, describe the mechanism of combinatorial treatment, and discuss regenerative rehabilitation in the context of SCI. Although conventional rehabilitative methods have commonly been implemented alone, especially in studies of acute-to-subacute SCI, the combinatorial effects of intensive and advanced methods, including various neurorehabilitative approaches, have also been reported. Separating the concept of combined rehabilitation from regenerative rehabilitation, we suggest that the main roles of regenerative rehabilitation can be categorized as conditioning/reconditioning, functional training, and physical exercise, all of which are indispensable for enhancing functional recovery achieved using stem cell therapies.
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U2 - 10.1038/s41536-021-00191-7
DO - 10.1038/s41536-021-00191-7
M3 - Review article
AN - SCOPUS:85119873865
SN - 2057-3995
VL - 6
JO - npj Regenerative Medicine
JF - npj Regenerative Medicine
IS - 1
M1 - 81
ER -