Curriculum vitae of intestinal intraepithelial T cells: Their developmental and behavioral characteristics

Hiromichi Ishikawa, Tomoaki Naito, Toshihiko Iwanaga, Hiromi Takahashi-Iwanaga, Makoto Suematsu, Toshifumi Hibi, Masanobu Nanno

研究成果: Review article査読

61 被引用数 (Scopus)


The alimentary tract has an epithelial layer, consisting mainly of intestinal epithelial cells (IECs), that is exposed to the exterior world through the intestinal lumen. The IEC layer contains many intestinal intraepithelial T cells (IELs), and the total number of IELs constitutes the largest population in the peripheral T-cell pool. Virtually all γδ-IELs and many αβ-IELs in the mouse small intestine are known to express CD8αα homodimers. A wide range of evidence that supports extrathymic development of these CD8αα+ IELs has been collected. In addition, while several studies identified cells with precursor T-cell phenotypes within the gut epithelium, how these precursors, which are dispersed along the length of the intestine, develop into γδ-IELs and/or αβ-IELs has not been clarified. The identification of lymphoid cell aggregations named 'cryptopatches' (CPs) in the intestinal crypt lamina propria of mice as sites rich in T-cell precursors in 1996 by our research group, however, provided evidence for a central site, whereby precursor IELs could give rise to T-cell receptor-bearing IELs. In this review, we discuss the development of IELs in the intestinal mucosa and examine the possibility that CPs serve as a production site of extrathymic IELs.

ジャーナルImmunological Reviews
出版ステータスPublished - 2007 2月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学


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