TY - JOUR
T1 - Cycloartane triterpenes isolated from Combretum quadrangulare in a screening program for death-receptor expression enhancing activity
AU - Toume, Kazufumi
AU - Nakazawa, Takafumi
AU - Ohtsuki, Takashi
AU - Arai, Midori A.
AU - Koyano, Takashi
AU - Kowithayakorn, Thaworn
AU - Ishibashi, Masami
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2011/2/25
Y1 - 2011/2/25
N2 - In our screening program for natural products that increase DR5 (death-receptor 5) expression, nine new cycloartane triterpenes, combretanones A-G (1-7), combretic acid A (8), and combretic acid B (9), were isolated from a MeOH extract of Combretum quadrangulare leaves. The known oleanane triterpenes (10, 11) and six known flavonols (12-17) were also isolated. The structures of 1-9 were elucidated by spectroscopic studies. Compounds 7, 9, 12, 16, and 17 enhanced DR5 expression, and 16 showed TRAIL-resistance abrogating activity.
AB - In our screening program for natural products that increase DR5 (death-receptor 5) expression, nine new cycloartane triterpenes, combretanones A-G (1-7), combretic acid A (8), and combretic acid B (9), were isolated from a MeOH extract of Combretum quadrangulare leaves. The known oleanane triterpenes (10, 11) and six known flavonols (12-17) were also isolated. The structures of 1-9 were elucidated by spectroscopic studies. Compounds 7, 9, 12, 16, and 17 enhanced DR5 expression, and 16 showed TRAIL-resistance abrogating activity.
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U2 - 10.1021/np100784t
DO - 10.1021/np100784t
M3 - Article
C2 - 21265555
AN - SCOPUS:79952303577
SN - 0163-3864
VL - 74
SP - 249
EP - 255
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 2
ER -