Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus

Tsutomu Sasaki; Kazuo Kitagawa; Shiro Sugiura; Emi Omura-Matsuoka; Shigeru Tanaka; Yoshiki Yagita; Hideyuki Okano; Masayasu Matsumoto; Masatsugu Hori

doi:10.1016/S0531-5131(03)00071-2

Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus

Tsutomu Sasaki, Kazuo Kitagawa, Shiro Sugiura, Emi Omura-Matsuoka, Shigeru Tanaka, Yoshiki Yagita, Hideyuki Okano, Masayasu Matsumoto, Masatsugu Hori

生理学

研究成果: Article › 査読

抄録

Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. The enhancement of dentate gyrus neurogenesis following ischemia was attenuated by COX inhibitors and in COX-2 knockout mice. These results demonstrate that COX-2 may modulate the enhancement of neurogenesis following ischemia.

本文言語	English
ページ（範囲）	445-450
ページ数	6
ジャーナル	International Congress Series
巻	1252
号	C
DOI	https://doi.org/10.1016/S0531-5131(03)00071-2
出版ステータス	Published - 2003 6月 1

ASJC Scopus subject areas

医学（全般）

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10.1016/S0531-5131(03)00071-2

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title = "Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus",

abstract = "Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. The enhancement of dentate gyrus neurogenesis following ischemia was attenuated by COX inhibitors and in COX-2 knockout mice. These results demonstrate that COX-2 may modulate the enhancement of neurogenesis following ischemia.",

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author = "Tsutomu Sasaki and Kazuo Kitagawa and Shiro Sugiura and Emi Omura-Matsuoka and Shigeru Tanaka and Yoshiki Yagita and Hideyuki Okano and Masayasu Matsumoto and Masatsugu Hori",

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T1 - Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus

AU - Sasaki, Tsutomu

AU - Kitagawa, Kazuo

AU - Sugiura, Shiro

AU - Omura-Matsuoka, Emi

AU - Tanaka, Shigeru

AU - Yagita, Yoshiki

AU - Okano, Hideyuki

AU - Matsumoto, Masayasu

AU - Hori, Masatsugu

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. The enhancement of dentate gyrus neurogenesis following ischemia was attenuated by COX inhibitors and in COX-2 knockout mice. These results demonstrate that COX-2 may modulate the enhancement of neurogenesis following ischemia.

AB - Global ischemia promotes neurogenesis in the dentate gyrus of the adult mouse hippocampus. Cyclooxygenase (COX)-2, the principal isoenzyme in the brain, modulates inflammation, glutamate-mediated cytotoxicity, and synaptic plasticity. The enhancement of dentate gyrus neurogenesis following ischemia was attenuated by COX inhibitors and in COX-2 knockout mice. These results demonstrate that COX-2 may modulate the enhancement of neurogenesis following ischemia.

KW - COX-2

KW - Hippocampus

KW - Musashi-1

KW - Neurogenesis

KW - Neuronal progenitor

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JO - International Congress Series

JF - International Congress Series

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Cyclooxygenase-2 is involved in increased proliferation of neuronal progenitor cells in the ischemic mouse hippocampus

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