Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

Yujiro Hayashi; Hiroaki Gotoh; Tomohiro Tamura; Hirofumi Yamaguchi; Ryouhei Masui; Mitsuru Shoji

doi:10.1021/ja055740s

Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

Yujiro Hayashi
, Hiroaki Gotoh
, Tomohiro Tamura
, Hirofumi Yamaguchi
, Ryouhei Masui
, Mitsuru Shoji

薬科学科

研究成果: Article › 査読

222 被引用数 (Scopus)

抄録

Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.

本文言語	English
ページ（範囲）	16028-16029
ページ数	2
ジャーナル	Journal of the American Chemical Society
巻	127
号	46
DOI	https://doi.org/10.1021/ja055740s
出版ステータス	Published - 2005 11月 23

ASJC Scopus subject areas

触媒
化学一般
生化学
コロイド化学および表面化学

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10.1021/ja055740s

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abstract = "Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.",

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AU - Masui, Ryouhei

AU - Shoji, Mitsuru

PY - 2005/11/23

Y1 - 2005/11/23

N2 - Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.

AB - Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities.

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Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

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ASJC Scopus subject areas

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