Cytotoxic principles of a Bangladeshi crude drug, akond mul (roots of Calotropis gigantea L.)

Fumiyuki Kiuchi, Yumi Fukao, Takuro Maruyama, Tohru Obata, Motohiro Tanaka, Takuma Sasaki, Masayuki Mirage, Mohammad Ekramul Haque, Yoshisuke Tsuda

研究成果: Article査読

54 被引用数 (Scopus)

抄録

Three cardenolide glycosides, calotropin (1), frugoside (2), and 4'-O- β-D-glucopyranosylfrugoside (3), were obtained as the cytotoxic principles of 'akond mul' (roots of Calotropis gigantea L.). The cytotoxicity of these compounds against various cell lines of human and mouse origin was tested. They showed similar cell line selectivity to those of cardiac glycosides such as digoxin and ouabain: they are toxic to cell lines of human origin, but not to those from mouse at 2 μg/ml.

本文言語English
ページ(範囲)528-530
ページ数3
ジャーナルChemical and Pharmaceutical Bulletin
46
3
DOI
出版ステータスPublished - 1998
外部発表はい

ASJC Scopus subject areas

  • 化学一般
  • 創薬

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