@article{aa85835190584d65a058cf66bb645195,
title = "Cytotoxicity and actin-depolymerizing activity of aplyronine A, a potent antitumor macrolide of marine origin, and its analogs",
abstract = "Artificial analogs of aplyronine A (1), a potent antitumor macrolide, were synthesized and structure-activity (cytotoxicity and actin-depolymerizing activity) relationships were investigated; the side-chain in 1 was found to play a key role in both biological activities.",
keywords = "Actin-depolymerizing, Analogs, Cytotoxicty, Marine metabolites, Structure-activity, Synthesis",
author = "Hideo Kigoshi and Kiyotake Suenaga and Masaki Takagi and Atsushi Akao and Kengo Kanematsu and Noriyuki Kamei and Youko Okugawa and Kiyoyuki Yamada",
note = "Funding Information: We are grateful to Professor Hirokazu Hotani and Drs Tomohiko Itoh and Kingo Takiguchi (Department of Molecular Biology, Graduate School of Science, Nagoya University) for their donation of actin and their helpful advice and discussions. We express our gratitude to Professor Daisuke Uemura (Department of Chemistry, Graduate School of Science, Nagoya University) for his interest in this work. We thank Dr Hisao Ekimoto and Ms Mutsuko Kimura (Nippon Kayaku Co., Ltd) for evaluating the cytotoxicity of the natural and synthetic compounds. This work was supported in part by Grants-in-Aid for Scientific Research on Priority Areas (K. Y.), for COE Research (H. K.), and for the Encouragement of Young Scientists (K. S.) from the Ministry of Education, Science, Sports, and Culture, Japan, the Fujisawa Foundation, Research Aid of Inoue Foundation for Science (K. S.), Suntory Institute for Bioorganic Research (H. K.), Ono Pharmaceutical Co., and Wako Pure Chemical Industries, Ltd (H. K.).",
year = "2002",
month = feb,
day = "4",
doi = "10.1016/S0040-4020(01)01206-6",
language = "English",
volume = "58",
pages = "1075--1102",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "6",
}
