抄録
Protein engineering has emerged as a powerful tool for engineering enzymes with new functions. We have been investigating an arylmalonate decarboxylase that acts on unnatural arylmalonates to give (R)-α-arylpropionates (profens). This chapter evaluates the potential use of directed evolution and rational design in completely changing the function of the decarboxylase to an artificial racemase and (S)-selective decarboxylase. The variants are useful biocatalysts for producing optically active profens.
| 本文言語 | English |
|---|---|
| ホスト出版物のタイトル | Green Biocatalysis |
| 出版社 | wiley |
| ページ | 59-70 |
| ページ数 | 12 |
| ISBN（電子版） | 9781118828083 |
| ISBN（印刷版） | 9781118822296 |
| DOI | |
| 出版ステータス | Published - 2016 5月 13 |
ASJC Scopus subject areas
- 工学（全般）
- 化学工学（全般）