TY - JOUR
T1 - Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction
AU - Yamamoto, Tsunehisa
AU - Endo, Jin
AU - Kataoka, Masaharu
AU - Matsuhashi, Tomohiro
AU - Katsumata, Yoshinori
AU - Shirakawa, Kosuke
AU - Yoshida, Naohiro
AU - Isobe, Sarasa
AU - Moriyama, Hidenori
AU - Goto, Shinichi
AU - Yamashita, Kaoru
AU - Nakanishi, Hiroki
AU - Shimanaka, Yuta
AU - Kono, Nozomu
AU - Shinmura, Ken
AU - Arai, Hiroyuki
AU - Fukuda, Keiichi
AU - Sano, Motoaki
N1 - Publisher Copyright:
© 2018 Yamamoto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2018/12
Y1 - 2018/12
N2 - Increase in saturated fatty acid (SFA) content in membrane phospholipids dramatically affects membrane properties and cellular functioning. We sought to determine whether exogenous SFA from the diet directly affects the degree of membrane phospholipid unsaturation in adult hearts and if these changes correlate with contractile dysfunction. Although both SFA-rich high fat diets (HFDs) and monounsaturated FA (MUFA)-rich HFDs cause the same degree of activation of myocardial FA uptake, triglyceride turnover, and mitochondrial FA oxidation and accumulation of toxic lipid intermediates, the former induced more severe diastolic dysfunction than the latter, which was accompanied with a decrease in membrane phospholipid unsaturation, induction of unfolded protein response (UPR), and a decrease in the expression of Sirt1 and stearoyl-CoA desaturase-1 (SCD1), catalyzing the conversion of SFA to MUFA. When the SFA supply in the heart overwhelms the cellular capacity to use it for energy, excess exogenous SFA channels to membrane phospholipids, leading to UPR induction, and development of diastolic dysfunction.
AB - Increase in saturated fatty acid (SFA) content in membrane phospholipids dramatically affects membrane properties and cellular functioning. We sought to determine whether exogenous SFA from the diet directly affects the degree of membrane phospholipid unsaturation in adult hearts and if these changes correlate with contractile dysfunction. Although both SFA-rich high fat diets (HFDs) and monounsaturated FA (MUFA)-rich HFDs cause the same degree of activation of myocardial FA uptake, triglyceride turnover, and mitochondrial FA oxidation and accumulation of toxic lipid intermediates, the former induced more severe diastolic dysfunction than the latter, which was accompanied with a decrease in membrane phospholipid unsaturation, induction of unfolded protein response (UPR), and a decrease in the expression of Sirt1 and stearoyl-CoA desaturase-1 (SCD1), catalyzing the conversion of SFA to MUFA. When the SFA supply in the heart overwhelms the cellular capacity to use it for energy, excess exogenous SFA channels to membrane phospholipids, leading to UPR induction, and development of diastolic dysfunction.
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U2 - 10.1371/journal.pone.0208396
DO - 10.1371/journal.pone.0208396
M3 - Article
C2 - 30533011
AN - SCOPUS:85058379817
SN - 1932-6203
VL - 13
JO - PloS one
JF - PloS one
IS - 12
M1 - e0208396
ER -