Defining the role of Lgr5⁺ stem cells in colorectal cancer: From basic research to clinical applications

Intestinal epithelium is structured by two distinct components: the villi and the crypts. The crypts harbor stem cells expressing Lgr5 and thus have been a representative model to study tissue stem cell functions. Recent advances in organoid technology and analytical modalities have enabled precise characterization of Lgr5⁺ intestinal stem cells, providing insights into their roles in homeostasis and cancer.