Deletion mapping on chromosome 1p in well-differentiated gastric cancer

T. Ezaki, A. Yanagisawa, K. Ohta, Sadakazu Aiso, M. Watanabe, T. Hibi, Y. Kato, T. Nakajima, T. Ariyama, J. Inazawa, Y. Nakamura, A. Horii

研究成果: Article査読

51 被引用数 (Scopus)


To define the region on the short arm of chromosome 1 that is thought to include one or more tumour-suppressor genes for gastric cancers, we carried out loss of heterozygosity (LOH) studies in 26 gastric adenocarcinomas, using three restriction fragment length polymorphism (RFLP) markers and nine microsatellite markers. All tumours were informative with at least one locus; three revealed replication errors (RERs) at multiple microsatellite loci, and interstitial or telomeric allelic deletions were observed in 12 cases. Deletion mapping of these tumours defined a commonly deleted region between two loci, D1S201 and D1S197, that are 13 cM apart. As two loci within the commonly deleted region, D1S57 (pYNZ2) and D1S62 (pTHI54), were mapped respectively to 1p35 and 1p34.3 by fluorescence in situ hybridisation, we conclude that a locus likely to contain a tumour-suppressor gene for gastric cancer is located within a 13 cM region encompassing these two chromosomal bands.

ジャーナルBritish Journal of Cancer
出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究


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