@article{aadeaeaafba640e3b9f320b77e15cb94,
title = "Derivation of human decidua-like cells from amnion and menstrual blood",
abstract = "We induced differentiation of human amnion-derived mesenchymal stem cells (AMCs) and menstrual blood-derived mesenchymal stem cells (MMCs) into endometrial stroma-like cells, which could be useful for cell therapy to support embryo implantation. Interestingly, the expression patterns of surface markers were similar among AMCs, MMCs, and endometrial stromal cells. In addition, whereas treatment with estrogen and progesterone was not very effective for decidualizing AMCs and MMCs, treatment with 8-Br-cAMP prompted remarkable morphological changes in these cells as well as increased expression of decidualization markers (prolactin and insulin-like growth factor binding protein-1) and attenuated expression of surface markers unique to mesenchymal stem cells. These results demonstrated that bone marrow-derived stem cells, which are considered a potential source of endometrial progenitor cells, as well as AMCs and MMCs show in vitro decidualization potential, which is characteristic of endometrial stromal cells.",
author = "Kana Sugawara and Toshio Hamatani and Mitsutoshi Yamada and Seiji Ogawa and Shintaro Kamijo and Naoaki Kuji and Hidenori Akutsu and Kenji Miyado and Yasunori Yoshimura and Akihiro Umezawa",
note = "Funding Information: We express our sincere thanks to Hatsune Makino, Kazumi Takanashi, Masanori Ihara, Tohru Sugawara, Yuichiro Harada, Yayoi Kajiwara, Tetsuo Maruyama, Hiroshi Uchida, Hirotaka Masuda, and other members of the National Research Institute for Child Health and Development and Keio University School of Medicine for valuable discussions and helpful advice. We also thank Kayoko Saito for secretarial work. This work was supported, in part, by a National Grant-in-Aid from the Japanese Ministry of Health, Labor, and Welfare (NCCHD24-6 to T.H. and H.A.), a Grant-in-Aid from the Japan Health Sciences Foundation (KHD1220 to T.H. and H.A.), and Grants-in-Aid from the Japan Society for the Promotion of Science (Kiban-C-23592413 to T.H. and Wakate-B-25861518 to K.S.).",
year = "2014",
month = apr,
day = "8",
doi = "10.1038/srep04599",
language = "English",
volume = "3",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}