@article{4cecd63f76f74fe9b0f74735b66c1d7a,
title = "Design, Synthesis, and Monoamine Oxidase Inhibitory Activity of (+)-Cinchonaminone and Its Simplified Derivatives",
abstract = "The absolute structure of an indole alkaloid (+)-cinchonaminone by total synthesis of both (+)-cinchonaminone and its enantiomer was determined. The main focus of the study was the enantioselective synthesis of both enantiomers of a chiral cis-3,4-disubstituted piperidine. We also evaluated monoamine oxidase (MAO) inhibitory activities of these enantiomers. Furthermore, its structurally simplified derivatives were synthesized that did not have any chiral center. Two of these derivatives showed stronger MAO inhibitory activities than that of (+)-cinchonaminone.",
keywords = "Total synthesis, absolute structure determination, indole alkaloid, monoamine oxidase (MAO) inhibitory activity, structurally simplified derivatives",
author = "Yuta Sato and Naoko Oyobe and Takao Ogawa and Sayo Suzuki and Hiroshi Aoyama and Tomonori Nakamura and Hiromichi Fujioka and Satoshi Shuto and Mitsuhiro Arisawa",
note = "Funding Information: This study was partially supported by a Grant-in-Aid from JSPS KAKENHI (Grant No. JP 15KT0063), by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number JP20am0101084, and by the Cooperative Research Program of “Network Joint Research Center for Materials and Devices” from the Ministry of Education, Culture, Sports, Science and Technology (MEXT). Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",
year = "2021",
month = sep,
day = "9",
doi = "10.1021/acsmedchemlett.1c00310",
language = "English",
volume = "12",
pages = "1464--1469",
journal = "ACS Medicinal Chemistry Letters",
issn = "1948-5875",
publisher = "American Chemical Society",
number = "9",
}