抄録
We have examined the expression of P-glycoprotein in clinical leukemic cell samples by using a monoclonal antibody (MRK16) against P-glycoprotein. We found that leukemia cells isolated from 3 out of 6 patients with blast crisis of chronic myelogenous leukemia were reactive to MRK16. These 3 cell lines expressed high levels of mdrl mRNA, which codes for P-glycoprotein. The present result indicates that the clinically refractory state of the tumor may be predicted in part by determining P-glycoprotein expression using the monoclonal antibody against P-glycoprotein, and the mdrl probe.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 1415-1419 |
| ページ数 | 5 |
| ジャーナル | Japanese Journal of Cancer Research GANN |
| 巻 | 78 |
| 号 | 12 |
| 出版ステータス | Published - 1987 |
| 外部発表 | はい |
ASJC Scopus subject areas
- 腫瘍学
- 癌研究
