Detection of Vaccine Adverse Events Before Package Insert Revisions Using a Japanese Spontaneous Reporting System

Shimon Suzuki, Shungo Imai, Satoru Mitsuboshi, Hayato Kizaki, Masayuki Hashiguchi, Satoko Hori

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The usefulness of disproportionality analysis for the pharmacovigilance of vaccines in the Japanese Adverse Drug Event Report (JADER) database is yet to be proven. This study aimed to verify whether significant disproportionality could be detected before adding new vaccine adverse event information to package inserts. Information on package insert revisions related to vaccine adverse drug events from January 2013 to March 2023 was extracted from the Pharmaceuticals and Medical Devices Agency website. This period was set as the maximum period for which early disproportionalities could be detected by the latest JADER database (April 2004 to December 2022). From JADER data, 15 revision histories (10 types of vaccines) of package inserts were identified, and 823,662 cases were obtained. Of the 15, 12 (80%) adverse events were identified as significant disproportionalities before package insert revisions were made. Nine of the 15 (60%) events were identified as significant disproportionalities earlier than at least 12 months. These findings suggest that the JADER database may detect vaccine adverse events earlier than package insert revisions, indicating its usefulness for the safety surveillance of vaccines.

本文言語English
ページ(範囲)903-908
ページ数6
ジャーナルJournal of Clinical Pharmacology
63
8
DOI
出版ステータスPublished - 2023 8月

ASJC Scopus subject areas

  • 薬理学
  • 薬理学(医学)

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