@article{f02cd09113774194b4270c62238764a1,
title = "Development of a luminescence-controllable firefly luciferin analogue using selective enzymatic cyclization",
abstract = "In this study, a new firefly luciferin analog that can switch firefly bioluminescence (BL) activity from {\textquoteleft}off{\textquoteright} to {\textquoteleft}on{\textquoteright} state was designed and synthesized. BL inactive N-Ac-γ-glutamate luciferin 3 contains an acyclic precursor of the thiazoline moiety. Enzymatic treatment of 3 with aminoacylase resulted in a smooth removal of the acyl protecting group and concomitant cyclization to provide BL active carboluciferin 2.",
keywords = "Bioluminescence, Enzyme detection, Firefly luciferase, Firefly luciferin derivative, Organic synthesis",
author = "Shuji Ioka and Tsuyoshi Saitoh and Maki, {Shojiro A.} and Masaya Imoto and Shigeru Nishiyama",
note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",
year = "2016",
doi = "10.1016/j.tet.2016.09.069",
language = "English",
volume = "72",
pages = "7505--7508",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Ltd",
number = "47",
}