TY - JOUR
T1 - Development of lecithinized superoxide dismutase as a drug for IPF
AU - Mizushima, Tohru
PY - 2014
Y1 - 2014
N2 - Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are thought to involve lung injury induced by reactive oxygen species (ROS), in particular superoxide anion. The enzyme, superoxide dismutase (SOD) catalyses the dismutation of superoxide anion to hydrogen peroxide. Lecithinized SOD (PC-SOD) has overcome a number of previous clinical limitations of SOD, including low tissue affinity and low stability in plasma. Recent animal studies suggest that PC-SOD is effective for the treatment of IPF and COPD. We are now performing the clinical study of PC-SOD for IPF patients.
AB - Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are thought to involve lung injury induced by reactive oxygen species (ROS), in particular superoxide anion. The enzyme, superoxide dismutase (SOD) catalyses the dismutation of superoxide anion to hydrogen peroxide. Lecithinized SOD (PC-SOD) has overcome a number of previous clinical limitations of SOD, including low tissue affinity and low stability in plasma. Recent animal studies suggest that PC-SOD is effective for the treatment of IPF and COPD. We are now performing the clinical study of PC-SOD for IPF patients.
KW - Idiopathic pulmonary fibrosis
KW - Reactive oxygen species
KW - Superoxide dismutase
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U2 - 10.1248/yakushi.13-00221-4
DO - 10.1248/yakushi.13-00221-4
M3 - Article
C2 - 24389620
AN - SCOPUS:84891643292
SN - 0031-6903
VL - 134
SP - 69
EP - 76
JO - Yakugaku Zasshi
JF - Yakugaku Zasshi
IS - 1
ER -