TY - GEN
T1 - Development of microfluidic droplet shooter for ultrahigh-sensitive mass spectrometry
AU - Kazoe, Yutaka
AU - Shimizu, Yusuke
AU - Terui, Yasushi
AU - Morikawa, Kyojiro
AU - Mawatari, Kazuma
AU - Kitamori, Takehiko
N1 - Funding Information:
The authors acknowledge Prof. Shigeru Terabe at University of Hyogo for fruitful discussion. This work was supported by a Social Cooperation Program on Next-Generation Analytical Instrumentation in School of Engineering, The University of Tokyo, Japan.
Publisher Copyright:
Copyright © (2018) by Chemical and Biological Microsystems Society. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Here we proposed and developed a microfluidic device to continuously shoot pL droplets toward controlled direction at kHz, and verified a novel sample injection interface with mass spectrometry (MS). Utilizing microscale laminar gas flows of 10 m/s enabled formation and shooting of uniform droplets and accurate trajectory control. On the contrary to a few percent sample injection rate by conventional electrospray ionization (ESI), the proposed microdroplet shooter can achieve 100% injection for ultrahigh sensitive MS detection. This study will open a new horizon for separation analysis, especially proteins and peptides which are important in state-of-the-art biological researches and medical diagnosis.
AB - Here we proposed and developed a microfluidic device to continuously shoot pL droplets toward controlled direction at kHz, and verified a novel sample injection interface with mass spectrometry (MS). Utilizing microscale laminar gas flows of 10 m/s enabled formation and shooting of uniform droplets and accurate trajectory control. On the contrary to a few percent sample injection rate by conventional electrospray ionization (ESI), the proposed microdroplet shooter can achieve 100% injection for ultrahigh sensitive MS detection. This study will open a new horizon for separation analysis, especially proteins and peptides which are important in state-of-the-art biological researches and medical diagnosis.
KW - Droplet
KW - Gas flow
KW - Mass spectrometry
KW - Microfluidics
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M3 - Conference contribution
AN - SCOPUS:85079878187
T3 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
SP - 989
EP - 990
BT - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PB - Chemical and Biological Microsystems Society
T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Y2 - 11 November 2018 through 15 November 2018
ER -