@article{c511ea97be4440898ba0dd4b7c34c3a5,
title = "Dietary iodine attenuates allergic rhinitis by inducing ferroptosis in activated B cells",
abstract = "Iodine-containing formulations have been widely used to treat iodine deficiency and as antiseptics. Lecithin-bound iodine (LBI) has been approved to treat allergic diseases in Japan; however, its underlying mechanism remains unknown. In this study, we show that LBI ameliorated disease symptoms in an ovalbumin (OVA)-induced allergic rhinitis mouse model. LBI suppressed OVA-specific IgE production by attenuating germinal center (GC) reaction in the draining lymph nodes. The antiallergic effect of LBI is most likely attributed to increased serum iodine levels but not thyroid hormone levels. In vitro treatment of activated B cells with potassium iodide induced ferroptosis by increasing intracellular reactive oxygen species (ROS) and ferrous iron in a concentration-dependent manner. Accordingly, LBI diets increased ROS levels in GC B cells of the draining lymph nodes. This study suggests that iodine directly promotes ferroptosis in activated B cells and attenuates GC reactions, leading to the alleviation of allergic symptoms.",
author = "Yutaka Nakamura and Yozen Fuse and Seiga Komiyama and Takahiro Nagatake and Jun Kunisawa and Koji Hase",
note = "Funding Information: We thank Dr. Daisuke Takahashi, Dr. Shunsuke Kimura, and Ryohtaroh Matsumoto of Keio University for their valuable suggestions. This study was supported by JSPS KAKENHI Grant Nos. 20H05876 and 22K19445 (to K.H.), and AMED CREST Grant No. 21gm1310009h0002 (to K.H.), and Daiichi Yakuhin Sangyo Co. LTD (to K.H.). We would like to thank Editage ( www.editage.com ) for English language editing. Funding Information: We thank Dr. Daisuke Takahashi, Dr. Shunsuke Kimura, and Ryohtaroh Matsumoto of Keio University for their valuable suggestions. This study was supported by JSPS KAKENHI Grant Nos. 20H05876 and 22K19445 (to K.H.), and AMED CREST Grant No. 21gm1310009h0002 (to K.H.), and Daiichi Yakuhin Sangyo Co. LTD (to K.H.). We would like to thank Editage (www.editage.com) for English language editing. Funding Information: This study was partly funded by Daiichi Yakuhin Sangyo Co., LTD (to K.H.). No other authors possess competing interests. Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
month = dec,
doi = "10.1038/s41598-023-32552-1",
language = "English",
volume = "13",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}