TY - JOUR
T1 - Differences in autoimmune hepatitis based on inflammation localization
AU - Takahashi, Atsushi
AU - Ohira, Hiromasa
AU - Abe, Kazumichi
AU - Zeniya, Mikio
AU - Abe, Masanori
AU - Arinaga-Hino, Teruko
AU - Torimura, Takuji
AU - Yoshizawa, Kaname
AU - Takaki, Akinobu
AU - Kang, Jong Hon
AU - Suzuki, Yoshiyuki
AU - Nakamoto, Nobuhiro
AU - Inui, Ayano
AU - Tanaka, Atsushi
AU - Takikawa, Hajime
N1 - Publisher Copyright:
© 2020, The Japanese Society for Clinical Molecular Morphology.
PY - 2021/3
Y1 - 2021/3
N2 - Histopathology is essential for the diagnosis and evaluation of disease activity of autoimmune hepatitis (AIH). We aimed to elucidate the characteristics of AIH from the localization of inflammation. We re-evaluated a nationwide survey that was performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017. A total of 303 patients were enrolled, and the clinical and treatment characteristics were compared between the patients with predominantly portal inflammation (230 patients) or lobular inflammation (73 patients). AIH patients with lobular inflammation had a higher probability of being diagnosed with acute hepatitis than those with portal inflammation. Liver enzyme levels were higher in patients with lobular inflammation, whereas immunoglobulin G levels were higher in patients with portal inflammation. The prevalence of an alanine aminotransferase level < 30 U/L after 6 months of treatment was significantly higher in patients with lobular inflammation than in those with portal inflammation (81.7% vs. 67.3%, P = 0.046). The localization of inflammation may be useful for evaluating the onset of AIH.
AB - Histopathology is essential for the diagnosis and evaluation of disease activity of autoimmune hepatitis (AIH). We aimed to elucidate the characteristics of AIH from the localization of inflammation. We re-evaluated a nationwide survey that was performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017. A total of 303 patients were enrolled, and the clinical and treatment characteristics were compared between the patients with predominantly portal inflammation (230 patients) or lobular inflammation (73 patients). AIH patients with lobular inflammation had a higher probability of being diagnosed with acute hepatitis than those with portal inflammation. Liver enzyme levels were higher in patients with lobular inflammation, whereas immunoglobulin G levels were higher in patients with portal inflammation. The prevalence of an alanine aminotransferase level < 30 U/L after 6 months of treatment was significantly higher in patients with lobular inflammation than in those with portal inflammation (81.7% vs. 67.3%, P = 0.046). The localization of inflammation may be useful for evaluating the onset of AIH.
KW - Acute hepatitis
KW - Autoimmune hepatitis
KW - Lobular inflammation
KW - Portal inflammation
KW - Treatment
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U2 - 10.1007/s00795-020-00255-5
DO - 10.1007/s00795-020-00255-5
M3 - Article
C2 - 32410010
AN - SCOPUS:85085027166
SN - 1860-1480
VL - 54
SP - 8
EP - 13
JO - Medical Molecular Morphology
JF - Medical Molecular Morphology
IS - 1
ER -
