TY - JOUR
T1 - Different intra-cerebrospinal distribution of linezolid in patients with inflammatory meningitis
AU - Ichinose, Naoki
AU - Yoshikawa, Gakushi
AU - Fukao, Eri
AU - Ichisawa, Mai
AU - Takahata, Tomoaki
AU - Enoki, Yuki
AU - Taguchi, Kazuaki
AU - Oda, Toshimi
AU - Tsutsumi, Kazuo
AU - Matsumoto, Kazuaki
N1 - Funding Information:
We would like to thank Editage (www.editage.com) for English language editing. , This research did not receive any specific grants from public or governmental funding agencies. All study participants provided informed consent. This study was approved by the Human Research Ethics Committee of Showa General Hospital (approval number REC-116) and the Ethics Committee for Research Involving Humans of Keio University Faculty of Pharmacy (approval number 161111-1). The authors have no competing interests to declare.
Publisher Copyright:
© 2021 The Author(s)
PY - 2021/9
Y1 - 2021/9
N2 - Linezolid has excellent antibiotic activity against gram-positive organisms and is expected to be an alternative to vancomycin for the treatment of bacterial meningitis. Accumulated evidence has shown the superior pharmacokinetic characteristics of linezolid to vancomycin, such as cerebrospinal fluid penetration. However, in the treatment of meningitis, pharmacokinetic information regarding the intra-cerebrospinal distribution of linezolid and the effects of drainage on the linezolid concentration in the cerebrospinal fluid are unclear. This report describes two patient cases, in which the linezolid concentrations in the cerebrospinal fluid were in the following order: subarachnoid space (cisternal drainage and lumbar puncture) ≥ third ventricle > lateral ventricle. In addition, the linezolid concentration in the cerebrospinal fluid, collected via lumbar puncture, tended to increase after removal of the drainage. This report is novel in presenting two cases of meningitis that showed different intra-cerebrospinal distribution of linezolid in various parts of the central nervous system and an increased linezolid concentration in the cerebrospinal fluid after removal of the drainage.
AB - Linezolid has excellent antibiotic activity against gram-positive organisms and is expected to be an alternative to vancomycin for the treatment of bacterial meningitis. Accumulated evidence has shown the superior pharmacokinetic characteristics of linezolid to vancomycin, such as cerebrospinal fluid penetration. However, in the treatment of meningitis, pharmacokinetic information regarding the intra-cerebrospinal distribution of linezolid and the effects of drainage on the linezolid concentration in the cerebrospinal fluid are unclear. This report describes two patient cases, in which the linezolid concentrations in the cerebrospinal fluid were in the following order: subarachnoid space (cisternal drainage and lumbar puncture) ≥ third ventricle > lateral ventricle. In addition, the linezolid concentration in the cerebrospinal fluid, collected via lumbar puncture, tended to increase after removal of the drainage. This report is novel in presenting two cases of meningitis that showed different intra-cerebrospinal distribution of linezolid in various parts of the central nervous system and an increased linezolid concentration in the cerebrospinal fluid after removal of the drainage.
KW - Cerebrospinal fluid
KW - Drainage
KW - Linezolid
KW - Meningitis
KW - Pharmacokinetic
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U2 - 10.1016/j.ijid.2021.08.001
DO - 10.1016/j.ijid.2021.08.001
M3 - Article
C2 - 34363968
AN - SCOPUS:85112836864
SN - 1201-9712
VL - 110
SP - 382
EP - 384
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
