Diphenylprolinol silyl ethers as efficient organocatalysts for the asymmetric Michael reaction of aldehydes and nitroalkenes

Yujiro Hayashi; Hiroaki Gotoh; Takaaki Hayashi; Mitsuru Shoji

doi:10.1002/anie.200500599

Diphenylprolinol silyl ethers as efficient organocatalysts for the asymmetric Michael reaction of aldehydes and nitroalkenes

Yujiro Hayashi
, Hiroaki Gotoh
, Takaaki Hayashi
, Mitsuru Shoji

研究成果: Article › 査読

1254 被引用数 (Scopus)

抄録

(Chemical Equation Presented) The direct, catalytic, asymmetric Michael addition of aldehydes to nitroolefins in the presence of a chiral diphenylprolinol silyl ether organocatalyst is described (see scheme). The desired 1,4-addition products were obtained in nearly optically pure form in good yield with high syn diastereoselectivity. TMS = trimethylsilyl.

本文言語	English
ページ（範囲）	4212-4215
ページ数	4
ジャーナル	Angewandte Chemie - International Edition
巻	44
号	27
DOI	https://doi.org/10.1002/anie.200500599
出版ステータス	Published - 2005 7月 4
外部発表	はい

ASJC Scopus subject areas

触媒
化学一般

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10.1002/anie.200500599

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引用スタイル

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AU - Gotoh, Hiroaki

AU - Hayashi, Takaaki

AU - Shoji, Mitsuru

PY - 2005/7/4

Y1 - 2005/7/4

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AB - (Chemical Equation Presented) The direct, catalytic, asymmetric Michael addition of aldehydes to nitroolefins in the presence of a chiral diphenylprolinol silyl ether organocatalyst is described (see scheme). The desired 1,4-addition products were obtained in nearly optically pure form in good yield with high syn diastereoselectivity. TMS = trimethylsilyl.

KW - Asymmetric catalysis

KW - Diphenylprolinol

KW - Michael addition

KW - Nitroalkenes

KW - Organocatalysis

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