TY - JOUR
T1 - Discovery of halogenated eurypamide B analogues as inhibitors of lipid droplet accumulation in macrophages
AU - Obata, Rika
AU - Ohshiro, Taichi
AU - Tomoda, Hiroshi
AU - Nishiyama, Shigeru
PY - 2005/10/1
Y1 - 2005/10/1
N2 - Halogenated cyclic isodityrosine-tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC50 value.
AB - Halogenated cyclic isodityrosine-tripeptides were synthesized as analogues of a marine natural product, eurypamide B. Although the original eurypamides showed no inhibitory activity, the new analogues were found to inhibit lipid droplet accumulation in macrophages with a low micromolar IC50 value.
KW - Antiatherosclerotic agents
KW - Cyclic isodityrosine
KW - Eurypamide
KW - Lipid droplet accumulation inhibitor
KW - Thallium(III) oxidation
UR - http://www.scopus.com/inward/record.url?scp=23944450117&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23944450117&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2005.06.070
DO - 10.1016/j.bmcl.2005.06.070
M3 - Article
C2 - 16054812
AN - SCOPUS:23944450117
SN - 0960-894X
VL - 15
SP - 4189
EP - 4191
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 19
ER -
