TY - JOUR
T1 - Disturbed tumor necrosis factor system is linked with lower eGFR and chronic inflammation in hypertension
AU - Eguchi, Takashi
AU - Maruyama, Tatsuya
AU - Ohno, Yoichi
AU - Morii, Toshiyuki
AU - Hirose, Hiroshi
AU - Takenaka, Tsuneo
AU - Suzuki, Hiromichi
AU - Kawabe, Hiroshi
AU - Saito, Ikuo
AU - Hayashi, Matsuhiko
AU - Itoh, Hiroshi
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Background: The relationship between tumor necrosis factor (TNF)-related parameters and cardiorenal metabolic factors is still controversial in clinical hypertension. Methods: Normotensive men (NT, n=60) and treated stage 2 and 3 essential hypertensive men (HT, n=89) were enrolled in this study. The relationship between TNF-related parameters and cardiorenal metabolic factors was examined in NT and HT, separately. Results: HT showed higher rates of insulin resistance and enhanced chronic inflammation compared with NT. The levels of soluble TNF receptor 1 and 2 were significantly higher in HT than in NT, although TNF-a levels were unexpectedly lower in HT than in NT. Regression analysis indicated that the TNF-related parameters were closely linked with mild renal dysfunction both in NT and HT, and moderately related to chronic inflammation only in HT. HT taking inhibitors of the renin-angiotensin system showed improved insulin resistance, but no difference in the TNF-related parameters. Conclusion: These results suggest that the disturbed TNF system is closely linked with chronic inflammation rather than with insulin resistance in HT.
AB - Background: The relationship between tumor necrosis factor (TNF)-related parameters and cardiorenal metabolic factors is still controversial in clinical hypertension. Methods: Normotensive men (NT, n=60) and treated stage 2 and 3 essential hypertensive men (HT, n=89) were enrolled in this study. The relationship between TNF-related parameters and cardiorenal metabolic factors was examined in NT and HT, separately. Results: HT showed higher rates of insulin resistance and enhanced chronic inflammation compared with NT. The levels of soluble TNF receptor 1 and 2 were significantly higher in HT than in NT, although TNF-a levels were unexpectedly lower in HT than in NT. Regression analysis indicated that the TNF-related parameters were closely linked with mild renal dysfunction both in NT and HT, and moderately related to chronic inflammation only in HT. HT taking inhibitors of the renin-angiotensin system showed improved insulin resistance, but no difference in the TNF-related parameters. Conclusion: These results suggest that the disturbed TNF system is closely linked with chronic inflammation rather than with insulin resistance in HT.
KW - Chronic inflammation
KW - Estimated glomerular filtration rate
KW - Insulin resistance
KW - Soluble tumor necrosis factor receptor
KW - Tumor necrosis factor
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U2 - 10.5301/jbm.5000049
DO - 10.5301/jbm.5000049
M3 - Article
C2 - 24170558
AN - SCOPUS:84897882690
SN - 0393-6155
VL - 29
SP - e69-e77
JO - International Journal of Biological Markers
JF - International Journal of Biological Markers
IS - 1
ER -
