DN-cadherin is required for spatial arrangement of nerve terminals and ultrastructural organization of synapses

Youichi Iwai, Yuki Hirota, Koichi Ozaki, Hideyuki Okano, Masatoshi Takeichi, Tadashi Uemura

研究成果: Article査読

61 被引用数 (Scopus)

抄録

We studied roles of DN-cadherin, the Drosophila major neuronal cadherin, in neuronal connections in the visual system. In DN-cadherin mutants, axon terminals of a large subset of photoreceptor cells reached and associated with their target interneurons, but their characteristic spatial arrangement was disrupted as synaptogenesis proceeded. Although synapses were formed at contact sites between the axon terminals and target neurons, underlycytoplasmic structures were not fully specialized at both pre- and postsynaptic terminals and synaptic vesicles appeared to accumulate at the presynapses. These results suggest that the cadherin adhesion system is required for interaction between pre- and postsynaptic terminals and for generation of the mature synaptic structures.

本文言語English
ページ(範囲)375-388
ページ数14
ジャーナルMolecular and Cellular Neuroscience
19
3
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 細胞および分子神経科学
  • 細胞生物学

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