Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

Lake Ee Quek; James R. Krycer; Satoshi Ohno; Katsuyuki Yugi; Daniel J. Fazakerley; Richard Scalzo; Sarah D. Elkington; Ziwei Dai; Akiyoshi Hirayama; Satsuki Ikeda; Futaba Shoji; Kumi Suzuki; Jason W. Locasale; Tomoyoshi Soga; David E. James; Shinya Kuroda

doi:10.1016/j.isci.2020.100855

Dynamic ¹³C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

Lake Ee Quek, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W. Locasale, Tomoyoshi Soga, David E. James, Shinya Kuroda

政策･メディア研究科

研究成果: Article › 査読

21 被引用数 (Scopus)

抄録

Biological

本文言語	English
論文番号	100855
ジャーナル	iScience
巻	23
号	2
DOI	https://doi.org/10.1016/j.isci.2020.100855
出版ステータス	Published - 2020 2月 21

ASJC Scopus subject areas

一般

文献へのアクセス

10.1016/j.isci.2020.100855

他のファイルとリンク

引用スタイル

Quek, L. E., Krycer, J. R., Ohno, S., Yugi, K., Fazakerley, D. J., Scalzo, R., Elkington, S. D., Dai, Z., Hirayama, A., Ikeda, S., Shoji, F., Suzuki, K., Locasale, J. W., Soga, T., James, D. E., & Kuroda, S. (2020). Dynamic ¹³C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin. iScience, 23(2), Article 100855. https://doi.org/10.1016/j.isci.2020.100855

Quek, LE, Krycer, JR, Ohno, S, Yugi, K, Fazakerley, DJ, Scalzo, R, Elkington, SD, Dai, Z, Hirayama, A, Ikeda, S, Shoji, F, Suzuki, K, Locasale, JW, Soga, T, James, DE & Kuroda, S 2020, 'Dynamic ¹³C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin', iScience, vol. 23, no. 2, 100855. https://doi.org/10.1016/j.isci.2020.100855

@article{a9b41eb4a0784c4cb68900c9cfc65c40,

title = "Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin",

abstract = "Biological",

keywords = "Biological Sciences, Flux Data, Metabolic Flux Analysis, Metabolomics",

author = "Quek, {Lake Ee} and Krycer, {James R.} and Satoshi Ohno and Katsuyuki Yugi and Fazakerley, {Daniel J.} and Richard Scalzo and Elkington, {Sarah D.} and Ziwei Dai and Akiyoshi Hirayama and Satsuki Ikeda and Futaba Shoji and Kumi Suzuki and Locasale, {Jason W.} and Tomoyoshi Soga and James, {David E.} and Shinya Kuroda",

note = "Funding Information: This work was supported by National Health and Medical Research Council (NHMRC) program grants ( GNT1061122 and GNT1086850 for D.E.J.). L.E.Q. was funded by the Judith and David Coffey Fund and Cancer Institute NSW ( CDF181241 ). J.R.K. was funded by an NHMRC Early Career Fellowship ( APP1072440 ), Australian Diabetes Society Skip Martin Early Career Fellowship, and Diabetes Australia Research Project grant. D.E.J. is an NHMRC Senior Principal Research Fellow ( APP1019680 ). S.K. was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST ( JPMJCR12W3 ) from the Japan Science and Technology Agency (JST) and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 17H06300 . T.S. was funded by the AMED-CREST from AMED , and from Yamagata prefectural government and the City of Tsuruoka. This research was supported by the Sydney Informatics Hub , funded by the University of Sydney . This research was facilitated by access to Sydney Mass Spectrometry, a core research facility at the University of Sydney. The contents of the published material are solely the responsibility of the authors and do not reflect the views of the NHMRC. K.Y. receives funding from the JSPS (KAKENHI grant numbers JP15H05582 and JP18H05431 ) and PRESTO ( JPMJPR1538 ) from the JST. Funding Information: This work was supported by National Health and Medical Research Council (NHMRC) program grants (GNT1061122 and GNT1086850 for D.E.J.). L.E.Q. was funded by the Judith and David Coffey Fund and Cancer Institute NSW (CDF181241). J.R.K. was funded by an NHMRC Early Career Fellowship (APP1072440), Australian Diabetes Society Skip Martin Early Career Fellowship, and Diabetes Australia Research Project grant. D.E.J. is an NHMRC Senior Principal Research Fellow (APP1019680). S.K. was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST (JPMJCR12W3) from the Japan Science and Technology Agency (JST) and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 17H06300. T.S. was funded by the AMED-CREST from AMED, and from Yamagata prefectural government and the City of Tsuruoka. This research was supported by the Sydney Informatics Hub, funded by the University of Sydney. This research was facilitated by access to Sydney Mass Spectrometry, a core research facility at the University of Sydney. The contents of the published material are solely the responsibility of the authors and do not reflect the views of the NHMRC. K.Y. receives funding from the JSPS (KAKENHI grant numbers JP15H05582 and JP18H05431) and PRESTO (JPMJPR1538) from the JST. Conceptualization, L.E.Q. and J.R.K.; Methodology, L.E.Q.; Software, L.E.Q.; Formal analysis, L.E.Q. and J.R.K.; Investigation, L.E.Q. J.R.K. D.J.F. S.D.E. A.H. S.I. F.S. and K.S.; Resources, T.S. S.K. and D.E.J.; Writing ? Original Draft, L.E.Q. J.R.K. S.K. and D.E.J.; Writing ? Review & Editing, all authors; Visualization, L.E.Q. and J.R.K.; Supervision, S.K. and D.E.J.; Fund Acquisition, J.R.K. S.K. and D.E.J. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

month = feb,

day = "21",

doi = "10.1016/j.isci.2020.100855",

language = "English",

volume = "23",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier Inc.",

number = "2",

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T1 - Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

AU - Quek, Lake Ee

AU - Krycer, James R.

AU - Ohno, Satoshi

AU - Yugi, Katsuyuki

AU - Fazakerley, Daniel J.

AU - Scalzo, Richard

AU - Elkington, Sarah D.

AU - Dai, Ziwei

AU - Hirayama, Akiyoshi

AU - Ikeda, Satsuki

AU - Shoji, Futaba

AU - Suzuki, Kumi

AU - Locasale, Jason W.

AU - Soga, Tomoyoshi

AU - James, David E.

AU - Kuroda, Shinya

N1 - Funding Information: This work was supported by National Health and Medical Research Council (NHMRC) program grants ( GNT1061122 and GNT1086850 for D.E.J.). L.E.Q. was funded by the Judith and David Coffey Fund and Cancer Institute NSW ( CDF181241 ). J.R.K. was funded by an NHMRC Early Career Fellowship ( APP1072440 ), Australian Diabetes Society Skip Martin Early Career Fellowship, and Diabetes Australia Research Project grant. D.E.J. is an NHMRC Senior Principal Research Fellow ( APP1019680 ). S.K. was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST ( JPMJCR12W3 ) from the Japan Science and Technology Agency (JST) and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 17H06300 . T.S. was funded by the AMED-CREST from AMED , and from Yamagata prefectural government and the City of Tsuruoka. This research was supported by the Sydney Informatics Hub , funded by the University of Sydney . This research was facilitated by access to Sydney Mass Spectrometry, a core research facility at the University of Sydney. The contents of the published material are solely the responsibility of the authors and do not reflect the views of the NHMRC. K.Y. receives funding from the JSPS (KAKENHI grant numbers JP15H05582 and JP18H05431 ) and PRESTO ( JPMJPR1538 ) from the JST. Funding Information: This work was supported by National Health and Medical Research Council (NHMRC) program grants (GNT1061122 and GNT1086850 for D.E.J.). L.E.Q. was funded by the Judith and David Coffey Fund and Cancer Institute NSW (CDF181241). J.R.K. was funded by an NHMRC Early Career Fellowship (APP1072440), Australian Diabetes Society Skip Martin Early Career Fellowship, and Diabetes Australia Research Project grant. D.E.J. is an NHMRC Senior Principal Research Fellow (APP1019680). S.K. was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST (JPMJCR12W3) from the Japan Science and Technology Agency (JST) and by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant Number 17H06300. T.S. was funded by the AMED-CREST from AMED, and from Yamagata prefectural government and the City of Tsuruoka. This research was supported by the Sydney Informatics Hub, funded by the University of Sydney. This research was facilitated by access to Sydney Mass Spectrometry, a core research facility at the University of Sydney. The contents of the published material are solely the responsibility of the authors and do not reflect the views of the NHMRC. K.Y. receives funding from the JSPS (KAKENHI grant numbers JP15H05582 and JP18H05431) and PRESTO (JPMJPR1538) from the JST. Conceptualization, L.E.Q. and J.R.K.; Methodology, L.E.Q.; Software, L.E.Q.; Formal analysis, L.E.Q. and J.R.K.; Investigation, L.E.Q. J.R.K. D.J.F. S.D.E. A.H. S.I. F.S. and K.S.; Resources, T.S. S.K. and D.E.J.; Writing ? Original Draft, L.E.Q. J.R.K. S.K. and D.E.J.; Writing ? Review & Editing, all authors; Visualization, L.E.Q. and J.R.K.; Supervision, S.K. and D.E.J.; Fund Acquisition, J.R.K. S.K. and D.E.J. The authors declare no competing interests. Publisher Copyright: © 2020 The Author(s)

PY - 2020/2/21

Y1 - 2020/2/21

N2 - Biological

AB - Biological

KW - Biological Sciences

KW - Flux Data

KW - Metabolic Flux Analysis

KW - Metabolomics

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