抄録
The configuration and conformation of a compound are critical factors that determine whether it can be accepted by an enzyme is a substrate or not. We have examined enzyme-catalyzed decarboxylation of some α-substituted malonic acids and proposed that the syn-periplanar conformation is required for the substrates to be bound to the active site of the enzyme. Theoretical calculation of potential energy surfaces also supports the conclusion from experimental results.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 469-475 |
| ページ数 | 7 |
| ジャーナル | Bioorganic and Medicinal Chemistry |
| 巻 | 2 |
| 号 | 6 |
| DOI | |
| 出版ステータス | Published - 1994 6月 |
ASJC Scopus subject areas
- 生化学
- 分子医療
- 分子生物学
- 薬科学
- 創薬
- 臨床生化学
- 有機化学