TY - JOUR
T1 - Effect of cyclic compressive stimuli on mechanical anisotropy of chondrocyte-seeded agarose gel culture
AU - Okuda, Yuya
AU - Konishi, Rei
AU - Miyata, Shogo
PY - 2013
Y1 - 2013
N2 - Recently tissue engineering therapy culturing autologous chondrocytes in vitro to create three dimensional tissue for the replacement of damaged tissue has been developed. Although the tissue engineering is a useful approach to reconstruct cartilage in vitro, the mechanical property of the engineered cartilage is not sufficient to replace natural cartilage. Within the natural cartilage, cells and collagen fibers, which are main components of the cartilage, align in response to the direction of cyclic deformations induced by daily walking or other activities. Due to this collagen fiber alignment, the cartilage has mechanical anisotropy. In this study, we focus on the beneficial effect of dynamic compressive loading on tissue regeneration for articular cartilage. The purpose of this study is to create mechanically anisotropic cartilage by compressive stimuli during the culture.
AB - Recently tissue engineering therapy culturing autologous chondrocytes in vitro to create three dimensional tissue for the replacement of damaged tissue has been developed. Although the tissue engineering is a useful approach to reconstruct cartilage in vitro, the mechanical property of the engineered cartilage is not sufficient to replace natural cartilage. Within the natural cartilage, cells and collagen fibers, which are main components of the cartilage, align in response to the direction of cyclic deformations induced by daily walking or other activities. Due to this collagen fiber alignment, the cartilage has mechanical anisotropy. In this study, we focus on the beneficial effect of dynamic compressive loading on tissue regeneration for articular cartilage. The purpose of this study is to create mechanically anisotropic cartilage by compressive stimuli during the culture.
KW - Anisotropy
KW - Bone and cartilage
KW - Orthopaedic biomechanics
KW - Regenerative medicine
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=84879995140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879995140&partnerID=8YFLogxK
U2 - 10.1299/kikaic.79.1736
DO - 10.1299/kikaic.79.1736
M3 - Article
AN - SCOPUS:84879995140
SN - 0387-5024
VL - 79
SP - 1736
EP - 1743
JO - Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C
JF - Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C
IS - 801
ER -